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Selank is a heptapeptide developed in Russia that offers anti-anxiety, cognitive-enhancing, and immunomodulatory effects, without causing sedation, addiction, or dependency. I. Basic Parameters
Full Name: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
CAS No.: 129954-34-3
Molecular Weight: 751.89 Da
Source: Institute of Molecular Genetics, Russian Academy of Sciences
Structure: The natural immunopeptide Tuftsin (TKPR) with a Pro-Gly-Pro sequence added to the C-terminus to enhance stability
Dosage Forms: Nasal Spray (Approved in Russia); Subcutaneous Injection (Research Use Only)
Status: Approved in Russia; Research Use Only in Europe and the US
II. Core Mechanisms (Triple Action)
Anxiolytic (GABAergic)
Enhances the activity of the GABA system, but does not directly bind to GABA-A receptors
Free from the sedation, drowsiness, addiction, and dependency associated with benzodiazepines
Cognitive Enhancement (Neurotrophic)
Rapidly increases BDNF (Brain-Derived Neurotrophic Factor) levels in the hippocampus
Promotes neuronal repair, enhances memory, and combats mental fatigue
Immunomodulation
Regulates IL-6 and the balance of Th1/Th2 cytokines
Anti-inflammatory, boosts immunity, and ameliorates stress-induced immune suppression
III. Key Benefits (Research + Clinical)
Potent Anxiolytic: Efficacy comparable to benzodiazepines, but without side effects or withdrawal symptoms
Alleviates Neurasthenia: Relieves fatigue, irritability, and poor concentration
Cognitive Enhancement: Improves memory, learning ability, and focus; protects against stress-induced cognitive decline
Mood Stabilization: Regulates serotonin and dopamine levels; acts as an antidepressant and anxiolytic
Immune Restoration: Corrects immune dysregulation caused by chronic stress and anxiety
IV. Synergies with Other Peptides of Interest
Selank + Oxytocin
Anxiolytic + Stress Reduction + Mood Stabilization + Enhanced Social Skills
Selank + NAD+/NMN
Neuronal Repair + Anti-Aging + Cognitive Enhancement + Cellular Energy Boost
Selank + BPC-157
Anxiolytic + Anti-inflammatory + Gastrointestinal Repair + Systemic Tissue Repair
Selank + Semax
The Classic Russian Combination: Selank (Anxiolytic) + Semax (Nootropic / Mental Stimulant)
V. Research Dosages (Reference)
Nasal Spray: 250–500 mcg per dose, 1–3 times per day ...per day
Subcutaneous Injection: 500 mcg – 1 mg per day
Cycle Duration: 14–21 days
Key Features: Rapid onset of action (15–30 minutes); effects last 4–6 hours
VI. One-Sentence Summary
Selank = A side-effect-free anti-anxiety peptide
A triple-action formula combining anti-anxiety, cognitive-enhancing, and immunomodulatory effects—without sedation, addiction potential, or dependency; officially approved in Russia.

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